Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis

R Lin; BV Taylor; S Simpson; J Charlesworth; AL Ponsonby; F Pittas; T Dwyer; IAF Van Der Mei

Journal article

Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis

R Lin, BV Taylor, S Simpson, J Charlesworth, AL Ponsonby, F Pittas, T Dwyer, IAF Van Der Mei

Journal of Neurology Neurosurgery and Psychiatry | Published : 2014

DOI: 10.1136/jnnp-2013-305245

Abstract

Background: The interplay between genes and environmental factors on multiple sclerosis (MS) clinical course has been little studied. Methods: We conducted a prospective cohort study of 141 participants with relapsing-remitting MS (RRMS) and genotype data followed from 2002 to 2005 and examined genes in the vitamin D metabolism and vitamin D receptor (VDR)/retinoid X receptor (RXR) transcription factor formation pathway. Gene- vitamin D interactions and the genetic predictors of relapse were assessed using survival analysis. Genetic predictors of 25-hydroxyvitamin D (25(OH)D) were evaluated by multilevel mixed-effects linear regression. Significance threshold was adjusted by Bonferroni corre..

View full abstract

University of Melbourne Researchers

Steve Simpson-Yap Author

Anne-Louise Ponsonby Author

Terry Dwyer Author Paediatrics Royal Children's Hospital

Related Projects (1)

NON-LEAD GRANT W/ MENZIES INST: IDENTIFYING RARE GENETIC VARIANTS CONFERRING SUSCEPTIBILITY TO MULTIPLE SCLEROSIS

Recently there has been success in identifying common genetic variants that confer susceptibility to multiple sclerosis. The variants that h..

Grants

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project 333105 and 605511). IvdM is supported by an Australian Research Council Future Fellowship. SSJ is supported by a Multiple Sclerosis Research Australia Postdoctoral Research Fellowship. A-LP is supported by an NHMRC Senior Research Fellowship.